Multicellular tumor spheroid formation in duplex microcapsules for analysis of chemosensitivity
نویسندگان
چکیده
منابع مشابه
Agent-Based Simulations of In Vitro Multicellular Tumor Spheroid Growth
Multicellular tumor spheroids (MTS) are an in vitro model system of avascular tumors. They are used to study how local microenvironments affect cellular growth, viability, and therapeutic response. We are developing in silico, agent-based analogues to provide new options for gaining exploitable insight into both the in vitro and in vivo systems. MTS exhibit characteristic phenotypic attributes:...
متن کاملMulticellular Tumor Spheroid Formation by Breast Cancer Cells Isolated from Different Sites1
Fourteen breast cancer lines (8 human, 5 rat, and 1 mouse) have been studied in terms of their ability to form multicellular tumor spheroids (MTS) with the agar-base method. Only 8 of the lines formed MTS in contrast to a 100% efficiency in a series of 11 varied tumors reported in the initial studies with this method. We have compared the lines that do and do not form MTS in terms of a variety ...
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abstract: mineral scaling in oil and gas production equipment is one of the most important problem that occurs while water injection and it has been recognized to be a major operational problem. the incompatibility between injected and formation waters may result in inorganic scale precipitation in the equipment and reservoir and then reduction of oil production rate and water injection rate. ...
Multicellular tumor spheroids in microcapsules as a novel 3D in vitro model in tumor biology
Background Advantages of microencapsulation as a 3D growth system are chemically and spatially defined 3D network of extracellular matrix components, cell-to-cell and cell-tomatrix interactions governing differentiation, proliferation and cell function in vivo. The study is aimed at i) optimization of techniques for preparing microcapsules; ii) generation of multicellular tumor spheroids (MTS) ...
متن کاملGeneration of core-shell microcapsules with three-dimensional focusing device for efficient formation of cell spheroid.
We present a microfluidic device generating three-dimensional (3D) coaxial flow by the addition of a simple hillock to produce an alginate core-shell microcapsule for the efficient formation of a cell spheroid. A hillock tapered at downstream of the two-dimensional focusing channel enables outside flow to enclose the core flow. The aqueous solution in the core flow was focused and surrounded by...
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ژورنال
عنوان ژورنال: Cancer Science
سال: 2012
ISSN: 1347-9032
DOI: 10.1111/j.1349-7006.2011.02187.x